DIPG-18. IDENTIFICATION OF TARGETABLE PATHWAY DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA
نویسندگان
چکیده
منابع مشابه
Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma.
Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using bromodomain inhibition or CDK7 blockade. Targeting oncogenic transcription through either of the...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2020
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noaa222.068